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Publications

Breast-Conserving Surgery

  • Macmillan RD, Purushotham AD, Mallon E, Ramsay G, George WD. Breast-conserving surgery and tumour bed positivity in patients with breast cancer. Br J Surg 1994;81:56-58.
  • Macmillan RD, Purushotham AD, Cordiner C, Dobson H, Mallon E, George WD. Prediction of local recurrence by pre-operative mammography in patients with breast cancer. Br J Radiol 1995;68:445-449.
  • Macmillan RD, Purushotham AD, George WD. Local recurrence following breast-conserving surgery for breast cancer. Br J Surg 1996;83:149-155.
  • Macmillan RD, Purushotham AD, Mallon E, Love JG, George WD. Tumour bed positivity predicts outcome after breast-conserving surgery. Br J Surg 1997;84:1559-1562.
  • Malik HZ, George WD, Mallon EA, Harnett AN, Macmillan RD, Purushotham AD. Margin assessment by cavity shaving after breast-conserving surgery - analysis and follow-up of 543 patients. Eur J Surg Oncol 1999; 25: 464-469.
  • Rampaul RS, Dudley NJ, Thompson JZ, Burrell H, Evans AJ, Wilson ARM, Macmillan RD. Radioisotope for occult lesion localisation (ROLL) of the breast does not require extra radiation protection measures. The Breast 2003;150-152.
  • Cochrane RA, Valassiadou P, Wilson ARM, Al-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg 2003;90:1505-1509.
  • Asgeirsson K, McCulley SJ, Pinder SE, Macmillan RD. Size of invasive breast cancer and risk of local recurrence after breast conserving therapy. Eur J Cancer 2003;39:2462-2469.
  • Macmillan RD, Cheung KL. Local recurrence and metastatic breast cancer. Surgery 2004;22:7.
  • Rampaul RS, Bagnall M, Burrell H, Pinder SE, Evans AJ, Macmillan RD. Radioisotope for occult lesion localisation: Results from a prospective randomised trial of ROLL versus wire guidance in occult lesions of the breast. Br J Surg 2004;91:1575-1577.
  • Chakrabarti J, Evans AJ, James J, Ellis IO, Pinder SE, Macmillan RD. Accuracy of mammography in predicting histological extent of ductal carcinoma in situ (DCIS). Eur J Surg Oncol 2006;32:1089-1092.
  • Cardoso MJ, Cardoso J, Amaral N, Azevedo I, Barreau L, Bernardo M, Christie D, Costa S, Fitzal F, Fougo JL, Johansen J, Macmillan D, Mano MP, Regalo L, Rosa J, Teixeira L, Vrieling C. Turning subjective into objective: The BCCT core software for evaluation of cosmetic results in breast cancer conservative treatment. The Breast 2007;16:456-461.
  • Tennant S, Evans A, Macmillan RD, Lee A, Cornford E, James J, Ellis IO. CT staging of loco-regional breast cancer recurrence. A worthwhile practice? Clin Radiol 2009;64:885-890.
  • Hodi Z, Ellis IO, Elston CW, Pinder SE, Donovan G, Macmillan RD, Lee AHS. Comparison of margin assessment by radial shave sections in wide local excision specimens for invasive carcinoma of the breast. Histopath 2010;56:573-580.

Mastectomy

  • Asgiersson KS, Holroyd B, Morgan DAL, Robertson JFR, Blamey RW, Pinder SE, Macmillan RD. Selective use of post-mastectomy flap irradiation in high-risk breast cancer patients. The Breast 2005; 14:298-303.

Oncoplastic Surgery

  • Asgiersson K, Rasheed T, McCulley SJ, Macmillan RD. Oncological and cosmetic outcomes of oncoplastic breast-conserving surgery. Eur J Surg Oncol 2005; 31:817-823.
  • McCulley SJ, Macmillan RD. Planning ans use of therapeutic mammaplasty -Nottingham approach. Br J Plast Surg 2005; 58:889-901.
  • McCulley SJ, Macmillan RD. Therapeutic mammaplasty - Analysis of 50 consecutive cases. Br J Plast Surg 2005; 58:901-907.
  • McCulley SJ, Durani P, Macmillan RD. Oncoplastic techniques for excising central tumours from the breast. Plast Reconstr Surg 2006;117:366-373.
  • Macmillan RD, Chan CW, McCulley SJ. Volume displacement techniques and therapeutic mammaplasty: the Nottingham experience. Advances in Breast Cancer 2008;5:10-12.
  • Chan CW. McCulley SJ. Macmillan RD. Autologous fat transfer--a review of the literature with a focus on breast cancer surgery.Journal of Plastic, Reconstructive & Aesthetic Surgery 2008;61:1438-48.
  • Cardoso MJ, Macmillan RD, Merck B, Munhoz AM, Rainsbury R. Training in oncoplastic surgery: An international consensus. The 7th Portuguese Senology Congress. Vilamoura, 2009. Breast 2010;19(6):538-40.
  • McCulley SJ, Macmillan RD, Rasheed T. Transverse Upper Gracilis (TUG) flap for volume replacement in breast conserving surgery for medial breast tumours in small to medium sized breasts. Journal of Plastic, Reconstructive & Aesthetic Surgery 2011;64(8):1056-60.

Management of the Axilla

  • Macmillan RD, Barbera D, Hadjiminas DJ, Rampaul RS, Lee AHS, Pinder SE, Ellis IO, Blamey RW, Geraghty JG. Sentinel node biopsy for breast cancer may have little to offer four-node-samplers: Results of a prospective comparison study. Eur J Cancer 2001;37:1076-1081.
  • Rampaul RS, Mullinger K, Macmillan RD, Cid J, Holmes S, Morgan DAL, Blamey RW. Incidence of clinically significant lymphoedema as a complication following surgery for primary operable breast cancer. Eur J Cancer 2003;39:2165-2167.
  • Damera A, Evans AJ, Cornford EJ, Wilson ARM, Burrell HC, James J, Pinder SE, Ellis IO, Lee A, Macmillan RD. Diagnosis of axillary node metastases by ultrasound guided core biopsy in primary operable breast cancer. Br J Cancer 2003;89:1310-1313.
  • Rampaul RS, Dale OT, Mitchell M, Blamey RW, Macmillan RD, Robertson JF, Ellis IO. Incidence of intramammary nodes in completion mastectomy specimens after node sampling: Implications for breast conserving surgery. The Breast 2008;17:195-198.
  • Paish EC, Green AR, Rakha EA, Macmillan RD, Maddison JR, Ellis IO. Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth. J Clin Pathol 2009;62:617-623.
  • Cornford EJ, James JJ, McMahon M, Macmillan RD, Lee AH. The importance of low-lying axillary sentinel nodes in breast cancer patients. Clin Rad 2011;66(10):974-6.

Familial Breast Cancer / Genetics

  • Macmillan RD. Screening women with a family history of breast cancer - Results from the British Familial Breast Cancer Group. Eur J Surg Oncol 2000; 26:149-152.
  • Mackay J, Rogers C, Fielder H, Blamey RW, Macmillan RD, Boggis C, Brown J, Pharoah PD, Moss S, Day WE, Myles J, Austoker J, Gray J, Cuzick J, Duffy SW. Development of a protocol for evaluation of mammographic surveillance services in women under 50 with a family history of breast cancer. J Epidemiol Biostat 2001; 6:365-369.
  • Iau PTC, Macmillan RD, Blamey RW. Germline mutations associated with breast cancer susceptibility. Eur J Cancer 2001;37:300-321.
  • Hamilton LJ, Evans AJ, Wilson ARM, Scott N, Cornford EJ, Pinder SE, Khan HN, Macmillan RD. Breast imaging findings in women with BRCA1 and BRCA2 associated breast cancer. Clin Rad 2004; 59:895-902.
  • Iau PTC, Marafie M, Macmillan RD, Pinder S, Denley HE, Ellis IO, Wenzyck P, Scott N, Cross G, Blamey RW. Are medullary breast cancers an indication for brca1 mutation screening? A mutation analysis of 42 cases of medullary breast cancer. Breast Cancer Res Treat 2004;85:81-88.
  • Henderson BJ, Tyndel S, Brain K, Clements A, Bankhead C, Austoker J, Watson E. PIMMS study management group. Duffy S, Evans G, Fielder H, Gray J, Mackay J, Macmillan D. Factors associated with breast cancer-specific distress in younger women participating in a family history mammography screening programme. Psycho-Oncology 2008;1774-82.
  • Brain K, Henderson BJ, Tyndel S, Bankhead C, Watson E, Clements A, Austoker J; PIMMS Study Management Group. Collaborators (6) Duffy S, Evans G, Fielder H, Gray J, Mackay J, Macmillan D. Predictors of breast cancer-related distress following mammography screening in younger women on a family history breast screening programme. Psychooncology. 2008;17(12):1180-8.
  • Tyndel S, Clements A, Bankhead C, Henderson BJ, Brain K, Watson E, Austoker J; PIMMS Study Management Group. Collaborators (6) Duffy S, Evans G, Fielder H, Gray J, Mackay J, Macmillan D. Mammographic screening for young women with a family history of breast cancer: knowledge and views of those at risk. Br J Cancer. 2008 Oct 7;99(7):1007-12.
  • FH01 Management Committee, Steering Committee and Collaborators. Tumour attributes and implications for future mortality in the FH01 study of mammographic surveillance in women aged 40-49 with a family history of breast cancer. Lancet Oncol. 2010; 11(12):1127-34.

Benign Breast Disorders / Risk Lesions

  • Macmillan RD, Robertson JFR. Benign disorders of the female breast. Current Obstetrics & Gynaecology 1998; 8:209-217.
  • Kollias J, Macmillan RD, Sibbering DM, Burrell H, Robertson JFR. The effect of Evening Primrose Oil on clinically diagnosed fibroadenomas. The Breast 2000; 9:35-36.
  • Macmillan RD, Dixon JM. Gynaecomastia. The Practitioner 2000; 244:785-787.
  • Macmillan RD. Nipple discharge. Surgery 2001; 19:5:109-110.
  • Lee AHS, Denley HE, Pinder SE, Ellis IO, Elston CW, Vujuvic P, Macmillan RD, Evans AE. Excision biopsy findings in patients with breast needle core biopsies reported as suspicious of malignancy (B4) or lesion of uncertain malignantpotential (B3). Histopath 2003;42:331-336.
  • Cid JA, Rampaul RS, Ellis IO, Evans AJ, Blamey RW, Macmillan RD. Woman feels breast lump - surgeon cannot. Role of ultrasound in arbitration. Eur J Cancer 2004; 40:2053-2055.

Prognosis

  • Hui R, Ball JR Macmillan RD, Kenny FS, Prall OWJ, Campbell DH, Cornish AL, McClelland RA, Daly RJ, Forbes JF, Blamey RW, Musgrove EA, Robertson JFR, Nicholson RI, Sutherland RL. EMS1 gene expression in primary breast cancer: Relationship to cyclin D1 and oestrogen receptor expression and patient survival. Oncogene 1998; 17:1053-1059.
  • Hui R, Macmillan RD, Kenny FS, Musgrove EA, Blamey RW, Nicholson RI, Robertson JFR, Sutherland RL. INK4a gene expression and methylation in primary breast cancer. Clin Cancer Res 2000;. 6:2777-2787.
  • James JJ, Evans AJ, Pinder SE, Macmillan RD, Wilson ARM, Ellis IO. Is the presence of mammographic comedo calcification really a prognostic factor for small screen-detected invasive breast cancers. Clin Rad 2003;58:54-62.
  • Lambie H, Miremadi A, Pinder SE, Bell JA, Wencyk P, Macmillan RD, Ellis IO. Prognostic significance of BRCA1 expression in sporadic breast carcinomas. J Pathol 2003;200:207-213.
  • Abd El-Rehim DM, Ball G, Pinder SE, Rakha E, Paish C, Robertson JFR, Macmillan D, Blamey RW, Ellis IO. High throughput protein expression analysis using Tissue Microarray Technology of a large well characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 2005;116:340-350.
  • Lee AHS, Pinder SE, Macmillan RD, Mitchell M, Ellis IO, Elston CW, Blamey RW. Prognostic value of lymphovascular invasion in women with lymph node negative breast carcinoma. Eur J Cancer 2006;42:357-362.
  • Rakha EA, El-Rehim DA, Paish C, Green AR, Lee AHS, Robertson JF, Blamey RW, Macmillan D, Ellis IO. Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance. Eur J Cancer 2006;42:3149-3156.
  • Blamey RW, Ellis IO, Pinder SE, Haybittle JL, Macmillan RD, Robertson JFR, Lee AHS, Mitchell MJ, Ball GR, Elston CW. Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990 to 1999. Eur J Cancer 2007;43:1548-1555.
  • Green AR, Burney C, Granger CJ, Paish EC, El-Sheikh S, Rakha EA, Powe DG, Macmillan RD, Ellis IO, Stylianou E. The prognostic significance of steroid receptor co-regulators in breast cancer: Co-repressor NCOR2/SMRT is an independent indicator of poor outcome. Br Cancer Res Treat 2008;110:427-437.
  • Habashy HO, Powel DG, Rakha EA, Ball G, Macmillan RD, Green AR, Ellis IO. The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype. Br Cancer Res Treat 2010;120:603-612.
  • Aleskandarany MA, Green AR, Rakha EA, Mohammed RA, Elsheikh SE, Powe DG, Paish EC, Macmillan RD, Chan S, Ahmed SI, Ellis IO.Growth fraction as a predictor of response to chemotherapy in node negative breast cancer. Int J Cancer 2010:126:1761-1769.
  • Aleskandarany MA, Rakha EA, Ahmed MA, Powe DG, Paish EC, Macmillan RD, Ellis IO, Green AR. PIK3CA expression in invasive breast cancer: a biomarker of poor prognosis. Breast Cancer Res Treat 2010;122(1):45-53.
  • Zhang H, Rakha EA, Ball GR, Spiteri I, Aleskandarany M, Paish EC, Powe DG, Macmillan RD, Caldas C, Ellis IO, Green AR. The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer. Breast Cancer Res Treat 2010;121:41-51.
  • Rakha EA, Lee AH, Evans AJ, Menon S, Assad NY, Hodi Z, Macmillan RD, Blamey RW, Ellis IO. Tubular carcinoma of the breast: Further evidence to support its excellent prognosis. J Clin Oncol 2010;28:99-104.
  • Soria D, Garibaldi JM, Ambrogi F, Green AR, Powe D, Rakha E, Macmillan RD, Blamey RW, Ball G, Lisboa PJ, Etchells TA, Boracchi P, Biganzoli E, Ellis IO. A methodology to identify consensus classes from clustering algorithms applied to immunohistochemical data from breast cancer patients. Comput Biol Med 2010;40:318-330.

  • Aleskandarany MA, Rakha EA, Macmillan RD, Powe DG, Ellis IO, Green AR. MIB1/Ki-67 labelling index can classify grade 2 breast cancer into two clinically distinct subgroups. Breast Cancer Research and Treatment. 2011;127(3):591-9.

  • Mohammed RA, Martin SG, Green A, Mahmood A, Macmillan RD, Paish EC, Ellis IO. Objective Assessment of Lymphatic and Blood Vascular Invasion in Lymph node Negative Breast Carcinoma: Findings From a Large Case Series With Long Term Follow Up. J Pathol. 2011; 223(3):358-65.

  • Habashy HO, Powe DG, Staka CM, Rakha EA, Ball G, Green AR, Aleskandarany M, Paish EC, Macmillan RD, Nicholson RI, Ellis IO, Gee JM. Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen. Breast Cancer Res 2010;119:283-293.
  • Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Lee AH, Ellis IO, Green AR. An evaluation of the clinical significance of FOXP3(+) infiltrating cells in human breast cancer. Breast Cancer Res Treat. 2011;127(1):99-108.
  • Mahmoud SM, Paish EC, Powe DG, Macmillan RD, Grainge MJ, Lee AH, Ellis IO, Green AR. Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer. J Clin Oncol. 2011; 29(15):1949-55.
  • Fernández B, Paish EC, Green AR, Lee AH, Macmillan RD, Ellis IO, Rakha EA. Lymph-node metastases in invasive lobular carcinoma are different from those in ductal carcinoma of the breast. Journal of Clinical Pathology;2011, 64(11):995-1000.
  • Mahmoud SM, Lee AH, Paish EC, Macmillan RD, Ellis IO, Green AR. The prognostic significance of B lymphocytes in invasive carcinoma of the breast. Breast Cancer Research and Treatment 2011; in press. 
  • Rakha EA, Gandhi N, Climent F, van Deurzen CH, Haider SA, Dunk L, Lee AH, Macmillan D, Ellis IO. Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis. Am J Surg Pathol 2011;35(8):1093-103
  • Mahmoud SM, Lee AH, Paish EC, Macmillan RD, Ellis IO, Green AR. Tumour-infiltrating macrophages and clinical outcome in breast cancer, J Pathol 2012 in press.
  • Agboola AJ, Paish EC, Rakha EA, Powe DG, Macmillan RD, Ellis IO, Green AR. EpCAM expression is an indicator of recurrence in basal-like breast cancer. Breast Cancer Research and Treatment 2012; in press.
  • Rakha EA, Martin S, Lee AH, Morgan D, Pharoah PD, Hodi Z, Macmillan D, Ellis IO. The prognostic significance of lymphovascular invasion in invasive breast carcinoma. Cancer 2012 in press.

Editorials

  • Macmillan RD, Rampaul RS, Blamey RW. Pre-operative ultrasound-guided node biopsy and sentinel node augmented node sample is best practice. Eur L Cancer 2003;40:176-178.
  • Macmillan RD, Blamey RW. The case for axillary node sampling. Adv Breast Cancer 2004;1:9-10.
  • Purushotham AD, Macmillan RD, Wishart GC. Advances in axillary surgery for breast cancer - time for a tailored approach. Eur J Surg Oncol 2005:31:929-931.
  • Macmillan RD. Ultrasound-guided node biopsy and blue dye assisted node sampling - not the only way but a good way. BASO Yearbook 2005.
  • Macmillan RD. The Oncoplastic Revolution. ABS Yearbook 2007.

PUBLISHED LETTERS

  • Purushotham AD, Macmillan RD, George WD. Breast-conserving surgery and tumour bed positivity in patients with breast cancer. Letter. Br J Surg 1994;81:922-923.
  • Macmillan RD, Rampaul RS, Blamey RW. Something Old, Something New, Something Hot, Something Blue. Eur J Cancer 2001;37:2135.
  • Macmillan RD, Rampaul RS, Blamey RW. Sentinel node biopsy. Lancet 2001;358:1815.

BOOK CHAPTERS

  • Macmillan RD. Clinical aspects of the diagnosis of breast calcification. In Diagnosing Breast Calcification.. Eds Evans AJ, Pinder SE, Wilson ARM and Ellis IO. GMM publishing 2001.
  • Blamey RW, Macmillan RD, Rampaul RS, Valassiadou P, Wahedna Y, Sibbering M, Pinder SE. DCIS - The Nottingham exerience. In Ductal Carcinoma In-Situ 2nd Edition.. Ed. Silverstein M. LWW publishing 2002.
  • Wilson ARM, Macmillan RD, Patnick J. Screening for Breast Cancer. In ABC of Breast Disease 3rd Edition. Ed Dixon M. BMJ publishing 2005.
  • Macmillan RD, Wilson ARM. Screening for Breast Cancer. In Companion to Surgical Practice. Ed Dixon M. 2006.
  • Macmillan RD. Overview of clinical aspects of breast disease. In Foundations in Diagnostic Pathology. Ed O'Malley FP, Pinder SE. Churchill Livingstone 2006.
  • Rampaul RS, Pinder SE, Macmillan RD, Ellis IO. Hormonal and genetic risk factors. In Preneoplasia of the Breast. Ed Boecher W. Saunders publishing 2006.
  • Macmillan RD. Oncoplastic Breast Surgery. In "So you want to be a brain surgeon". 2008.
  • McCulley SJ, Macmillan RD. Oncoplastic reconstruction of central defects. In Partial Breast Reconstruction: New Horizons in Oncoplastic Surgery. Ed Losken A, Hamdi M. 2008.
  • Macmillan RD, Wilson ARM. Screening for Breast Cancer. In Companion to Specialist Surgical Practices. Ed Dixon M. 2008.
  • Macmillan RD. Mastectomy for Breast Cancer: Tips and Pitfalls. In Companion to Specialist Surgical Practices. Ed Dixon M. 2008.
  • Macmillan RD. Overview of clinical aspects of breast disease. 2nd Ed. In Foundations in Diagnostic Pathology. Ed O’Malley FP, Pinder SE. Churchill Livingstone 2010.
  • Macmillan RD, McCulley SJ. Variations in classical reduction patterns for oncoplastic purposes. In Oncoplastic and Reconstructive Surgery of the Breast. 2nd Ed. Informa. 2011.
  • McCulley SJ, Macmillan RD. Correction of breast deformity following breast conserving surgery. In Oncoplastic and Reconstructive Surgery of the Breast. 2nd Ed. Informa. 2011.

ON-LINE PUBLICATIONS

  • Macmillan RD, George WD. Current issues regarding local recurrence after breast-conserving surgery. Invited Review Article. Breast Cancer On-line 1998; www.bco.org.
  • Macmillan RD. Review of the 1st Milan Breast Cancer Conference. Breast Cancer On-line 1999; www.bco.org.
  • Rampaul RS, Burrell H, Evans AJ, Macmillan RD, Ellis IO. A Tale of Two Axillas. Breast Cancer On-line 2001; www.bco.org.
  • Rampaul RS, Thompson JZ, Burrell HC, Macmillan RD. The advantage of post-injection mammography in radio-isotope lesion localisation (ROLL) of the breast. 2003; www.bco.org.
  • Rampaul RS, Burrell HC, Evans AJ, Macmillan RD, Ellis IO. The fibroadenoma factory. 2003; www.bco.org.

CASE REPORTS

  • Rampaul RS, Burrell H, Macmillan RD, Evans AJ. Intraductal injection of the breast - a potential pitfall of radioisotope occult lesion localisation. Br J Radiol 2002;76:425-426.
  • Raj N, Macmillan RD, Ellis IO, Deighton CM. Rheumatologists and breasts: Immunosuppressive therapy for granulomatous mastitis. J Rheumatol 2004;43:1055-1063.